Cannabis extract shrinks brain tumours

circpro

No Complaints here
#1
http://www.newscientist.com/article.ns?id=dn6283

Cannabis extract shrinks brain tumours

Cannabis extracts may shrink brain tumours and other cancers by blocking the growth of the blood vessels which feed them, suggests a new study.

An active component of the street drug has previously been shown to improve brain tumours in rats. But now Manuel Guzmán at Complutense University, Spain, and colleagues have demonstrated how the cannabis extracts block a key chemical needed for tumours to sprout blood vessels – a process called angiogenesis.

And for the first time, the team has shown the cannabinoids impede this chemical in people with the most aggressive form of brain cancer - glioblastoma multiforme.

Cristina Blázquez at Complutense University, and one of the team, stresses the results are preliminary. “But it’s a good point to start and continue,” she told New Scientist.

“The cannabinoid inhibits the angiogenesis response - if a tumour doesn’t do angiogenesis, it doesn’t grow,” she explains. “So if you can improve angiogenesis on one side and kill the tumour cells on the other side, you can try for a therapy for cancer.”

"This research provides an important new lead compound for anti-cancer drugs targeting cancer's blood supply,” says Richard Sullivan, head of clinical programmes, at Cancer Research UK.
Fat molecule

The team tested the effects of delta-9-tetrahydrocannabinol in 30 mice. They found the marijuana extract inhibited the expression of several genes related to the production of a chemical called vascular endothelial growth factor (VEGF).

VEGF is critical for angiogenesis, which allows tumours to grow a network of blood vessels to supply their growth. The cannabinoid significantly lowered the activity of VEGF in the mice and two human brain cancer patients, the study showed.

The drug did this by increasing the activity of a fat molecule called ceramide, suggests the study, as adding a ceramide inhibitor stifled the ability of the cannabinoid to block VEGF.
Small and pallid

“We saw that the tumours [in mice] were smaller and a bit pallid,” adds Blázquez. The paleness of the cancer reflected its lack of blood supply as a result of the treatment. In the human patients, she says: "It seems that it works, but it's very early."

Sullivan points out: “Although this work is at an early stage of development other research has already demonstrated that VEGF is an important drug target for a range of cancers.”

He emphasises the need for further work on cannabinoid combinations. “Cannabinoids would need to generate very strong data in the future as there are already a number of VEGF inhibitors in clinical development,” he says.

The two patients in the ongoing study are among 14 in a clinical trial of the drug. The patients are given one cycle of treatment, lasting a few days, and their survival and general health are being studied.
 

tattered

Uber-Aryan
Wackbag Staff
#3
one more nail in the governments coffin in their fight against a weed
 

LiddyRules

Regional Sales Rep for Fontaine Fish Finder
#4
tattered said:
one more nail in the governments coffin in their fight against a weed
One more nail or one more weapon in their arsenal?

Listen, the government needs to do more research into weed before they can contemplate making it legal. (Fuck you John Kerry, I'm still bitter.)Who cares that the more research they do, the better pot comes out?

Listen, it helps people. Yes. It might shrink brain tumors? Sure. But I saw a commercial where a talking dog had to walk himself, he went to a park, and planted a flag. If that doesn't show you why pot is bad then...then, you're liberal. Sorry, it had to be said.
 
#5
The problem is smoking it isn't enough, it's high concentrations that are required.
 

THE FEZ MAN

as a matter of fact i dont have 5$
#6
abudabit said:
The problem is smoking it isn't enough, it's high concentrations that are required.
since i am a glass blower im sure that i could figgure out a few differnt ways to build stills to refine it. the internet is a wonderfull thing
 
#7
I've been smoking for 33 years my brain is half as big as when i started.
Wait what!!!!
Never mine:icon_mrgr
 
#8
Oil, if you fume the oil instead of burn it you can take massive pot in. You heat the glass up with a strong lighter from the outside while the oil is inside. You need a special pipe though. Medical marijuana extract would be amazing, if it were complete. You would get SO high with no lung damage.

Edit Look up vaporizers, you can copy a vaporizer design. The oil has to get like 400 degrees though and that's through the glass so an ordinary lighter won't work.
 

THE FEZ MAN

as a matter of fact i dont have 5$
#9
see and the right says pot heads loose there ambiton and get stupider duuuuhh were was i ?
 

LiddyRules

Regional Sales Rep for Fontaine Fish Finder
#10
abudabit said:
Oil, if you fume the oil instead of burn it you can take massive pot in. You heat the glass up with a strong lighter from the outside while the oil is inside. You need a special pipe though. Medical marijuana extract would be amazing, if it were complete. You would get SO high with no lung damage.

Edit Look up vaporizers, you can copy a vaporizer design. The oil has to get like 400 degrees though and that's through the glass so an ordinary lighter won't work.
I never thought I'd get to say this...

Time to call in Stephen Baldwin.
 
#11
Alternative medicine are more accepted now a days due to it's promising results unlike pharmaceutical medicine, alternative medicine don't give negative effect such as kidney and liver problems when it comes to long term use. As for my alternative medicine usage, I use medical marijuana. Different strain has a variety of uses and effect depending on your needs. You may check this https://www.gyo.green/cannabis-seed-lists
 

Creasy Bear

gorgeousness and gorgeousity made flesh
Donator
#12
Alternative medicine are more accepted now a days due to it's promising results unlike pharmaceutical medicine, alternative medicine don't give negative effect such as kidney and liver problems when it comes to long term use. As for my alternative medicine usage, I use medical marijuana. Different strain has a variety of uses and effect depending on your needs. You may check this https://www.gyo.green/cannabis-seed-lists
I need to get zooted.
 

Mags

LDAR, bitch.
Donator
#15
Alternative medicine are more accepted now a days due to it's promising results unlike pharmaceutical medicine, alternative medicine don't give negative effect such as kidney and liver problems when it comes to long term use. As for my alternative medicine usage, I use medical marijuana. Different strain has a variety of uses and effect depending on your needs. You may check this https://www.gyo.green/cannabis-seed-lists
Fuckin pot head.
 
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